β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching
نویسندگان
چکیده
منابع مشابه
β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.
Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-s...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2015
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc07189e